翻訳と辞書 Words near each other ・ Interleukin 5 receptor alpha subunit ・ Interleukin 6 ・ Interleukin 7 ・ Interleukin 8 ・ Interleukin 8 receptor, alpha ・ Interleukin 8 receptor, beta ・ Interleukin 9 ・ Interleukin receptor ・ Interleukin-1 receptor ・ Interleukin-1 receptor family ・ Interleukin-1 receptor-associated kinase ・ Interleukin-1 receptor–associated kinase 4 deficiency ・ Interleukin-10 receptor ・ Interleukin-11 receptor ・ Interleukin-12 receptor ・ Interleukin-13 receptor ・ Interleukin-15 receptor ・ Interleukin-17 receptor ・ Interleukin-18 receptor ・ Interleukin-20 receptor ・ Interleukin-21 receptor ・ Interleukin-22 receptor ・ Interleukin-23 receptor ・ Interleukin-27 receptor ・ Interleukin-28 receptor ・ Interleukin-3 receptor ・ Interleukin-36 ・ Interleukin-4 receptor ・ Interleukin-5 receptor ・ Interleukin-6 receptor Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Interleukin-13 receptor ： ウィキペディア英語版 Interleukin-13 receptor The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin. There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. This binds IL-13 with very high affinity (and can therefore sequester it) but does not allow IL-4 binding. It acts as a negative regulator of both IL-13 and IL-4, however the mechanism of this is still undetermined.〔Seyfizadeh, N., Seyfizadeh, N., Babaloo, Z. (2014). ("Interleukin-13 as an Important Mediator: A Review on its Roles in Some Human Diseases" ), ''Iranian Journal of Allergy, Asthma and Immunology'', In Press.〕 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Interleukin-13 receptor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.